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1

Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

Yan Li, David H. Chen, Jian Yan, Ying Chen, Roberta A. Mittelstaedt, Yongbin Zhang, Alexandru S. Biris, Robert H. Heflich, Tao Chen

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2012

Langue:

english

Fichier:

PDF, 461 KB

english, 2012

2

Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes

Vasily N. Dobrovolsky, Tao Chen, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1999

Langue:

english

Fichier:

PDF, 146 KB

english, 1999

3

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea – comparison with other in vivo genotoxicity endpoints

Zoryana Cammerer, Javed A. Bhalli, Xuefei Cao, Stephanie L. Coffing, Donna Dickinson, Krista L. Dobo, Vasily N. Dobrovolsky, Maria Engel, Ronald D. Fiedler, William C. Gunther, Robert H. Heflich, Maso

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2011

4

In vivo assessment of Pig-a gene mutation—recent developments and assay validation

Stephen D. Dertinger, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 58 KB

english, 2011

5

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup

Gollapudi, B. Bhaskar, Lynch, Anthony M., Heflich, Robert H., Dertinger, Stephen D., Dobrovolsky, Vasily N., Froetschl, Roland, Horibata, Katsuyoshi, Kenyon, Michelle O., Kimoto, Takafumi, Lovell, Dav

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

2015

Langue:

english

Fichier:

PDF, 846 KB

english, 2015

6

Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide

De-Jin Zhan, Robert H. Heflich, Peter P. Fu

Journal:

Environmental and Molecular Mutagenesis

Année:

1996

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1996

7

DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene

Robert H. Heflich, Roberta A. Mittelstaedt, Mugimane G. Manjanatha, Lascelles E. Lyn-Cook, Anane Aidoo

Journal:

Environmental and Molecular Mutagenesis

Année:

1996

Langue:

english

Fichier:

PDF, 799 KB

english, 1996

8

Other transgenic mutation assays: Development of a novel mouse tk+/− embryonic stem cell line for use in mutagenicity studies

Vasily N. Dobrovolsky, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1996

Langue:

english

Fichier:

PDF, 663 KB

english, 1996

9

Molecular characterization of hprt mutations from chinese hamster ovary cells treated with 1-, 3-, and 6-Nitrosobenz[a]pyrene

De-Jin Zhan, Li-Hsueh Chiu, Robert H. Heflich, Peter P. Fu

Journal:

Environmental and Molecular Mutagenesis

Année:

1998

Langue:

english

Fichier:

PDF, 93 KB

english, 1998

10

Expansion of rat 6-thioguanine-resistant T-lymphocyte clones by stimulation with ionomycin and a phorbol ester

Tao Chen, Anane Aidoo, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1998

Langue:

english

Fichier:

PDF, 137 KB

english, 1998

11

Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue® rats

Roberta A. Mittelstaedt, Mugimane G. Manjanatha, Sharon D. Shelton, Lascelles E. Lyn-Cook, James B. Chen, Anane Aidoo, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1998

Langue:

english

Fichier:

PDF, 141 KB

english, 1998

12

Mutational response at the splenic T-Lymphocyte hprt locus in mice treated as neonates: Contrasting effects of the carcinogens N-ethyl-N-nitrosourea, dimethylnitrosamine, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

S. Balachandra Dass, Robert H. Heflich, Daniel A. Casciano

Journal:

Environmental and Molecular Mutagenesis

Année:

1998

Langue:

english

Fichier:

PDF, 138 KB

english, 1998

13

Sensitivity of the ΦX174 am3 allele in relation to the endogenous Hprt gene for detecting mutation in transgenic mice

James B. Chen, S. Balachandra Dass, James G. Burkhart, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1998

Langue:

english

Fichier:

PDF, 159 KB

english, 1998

14

Detection of basepair substitution mutation at a frequency of 1 × 10−7 by combining two genotypic selection methods, MutEx enrichment and allele-specific competitive blocker PCR

Barbara L. Parsons, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1998

Langue:

english

Fichier:

PDF, 361 KB

english, 1998

15

7,12-dimethylbenz[a]anthracene-induced mutation in the Tk gene of Tk+/− mice: Automated scoring of lymphocyte clones using a fluorescent viability indicator

Vasily N. Dobrovolsky, Joseph G. Shaddock, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2000

Langue:

english

Fichier:

PDF, 194 KB

english, 2000

16

A Response-Additive Model for Analyzing Mixtures of Two Chemicals in the Salmonella Reversion Assay

Dr. James J. Chen, Robert H. Heflich, Bruce S. Hass

Journal:

Biometrical Journal

Année:

1989

Langue:

english

Fichier:

PDF, 524 KB

english, 1989

17

On the use of the T-REx™ tetracycline-inducible gene expression system in vivo

Vasily N. Dobrovolsky, Robert H. Heflich

Journal:

Biotechnology and Bioengineering

Année:

2007

Langue:

english

Fichier:

PDF, 223 KB

english, 2007

18

Editorial

Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2002

Langue:

english

Fichier:

PDF, 37 KB

english, 2002

19

Mutagenicity of γ-radiation, mitomycin C, and etoposide in the Hprt and Tk genes of Tk+/− mice

Vasily N. Dobrovolsky, Joseph G. Shaddock, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2002

Langue:

english

Fichier:

PDF, 117 KB

english, 2002

20

Editorial

Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2002

Langue:

english

Fichier:

PDF, 34 KB

english, 2002

21

The Journal celebrates an anniversary

Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2004

Langue:

english

Fichier:

PDF, 31 KB

english, 2004

22

Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene–treated Big Blue® rats

Tao Chen, Roberta A. Mittelstaedt, Anane Aidoo, L. Patrice Hamilton, Frederick A. Beland, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2001

Langue:

english

Fichier:

PDF, 115 KB

english, 2001

23

Gene- and tissue-specificity of mutation in Big Blue® rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene

Tao Chen, Roberta A. Mittelstaedt, Sharon D. Shelton, S. Balachandra Dass, Mugimane G. Manjanatha, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2001

Langue:

english

Fichier:

PDF, 102 KB

english, 2001

24

Special section: The 25th anniversary of Environmental and Molecular Mutagenesis

Suzanne M. Morris, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2004

Langue:

english

Fichier:

PDF, 33 KB

english, 2004

25

Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine

Linda S. Von Tungeln, Lee D. Williams, Daniel R. Doerge, Joseph G. Shaddock, Lynda J. McGarrity, Suzanne M. Morris, Roberta A. Mittelstaedt, Robert H. Heflich, Frederick A. Beland

Journal:

Environmental and Molecular Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 194 KB

english, 2007

26

Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC

Vasily N. Dobrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt, Michelle E. Bishop, Sherry M. Lewis, Fei W. Lee, Anane Aidoo, Julian E.A. Leakey, June K. Dunnick, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 281 KB

english, 2007

27

Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice

Sachin V. Bendre, Joseph G. Shaddock, Vasily N. Dobrovolsky, Richard J. Albertini, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 294 KB

english, 2007

28

Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants

Daishiro Miura, Vasily N. Dobrovolsky, Roberta A. Mittelstaedt, Yoshinori Kasahara, Yasuhiro Katsuura, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2008

Langue:

english

Fichier:

PDF, 365 KB

english, 2008

29

Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat

Daishiro Miura, Vasily N. Dobrovolsky, Yoshinori Kasahara, Yasuhiro Katsuura, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2008

Langue:

english

Fichier:

PDF, 351 KB

english, 2008

30

Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice

Tao Chen, Robert H. Heflich, Martha M. Moore, Nan Mei

Journal:

Environmental and Molecular Mutagenesis

Année:

2010

Langue:

english

Fichier:

PDF, 121 KB

english, 2010

31

Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats

Vasily N. Dobrovolsky, Sherin Y. Boctor, Nathan C. Twaddle, Daniel R. Doerge, Michelle E. Bishop, Mugimane G. Manjanatha, Takafumi Kimoto, Daishiro Miura, Robert H. Heflich, Sherry A. Ferguson

Journal:

Environmental and Molecular Mutagenesis

Année:

2010

Langue:

english

Fichier:

PDF, 443 KB

english, 2010

32

The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment

Vasily N. Dobrovolsky, Daishiro Miura, Robert H. Heflich, Stephen D. Dertinger

Journal:

Environmental and Molecular Mutagenesis

Année:

2010

Langue:

english

Fichier:

PDF, 608 KB

english, 2010

33

The 40th anniversary of the Environmental Mutagen Society

Suzanne M. Morris, Anane Aidoo, Vasily Dobrovolsky, Robert Heflich, Mugimane Manjanatha, Page McKinzie, Barbara Parsons

Journal:

Environmental and Molecular Mutagenesis

Année:

2010

Langue:

english

Fichier:

PDF, 29 KB

english, 2010

34

Analysis of mutations in the Pig-a gene of spleen T-cells from N-ethyl-N-nitrosourea-treated fisher 344 rats

Daishiro Miura, Joseph G. Shaddock, Roberta A. Mittelstaedt, Vasily N. Dobrovolsky, Takafumi Kimoto, Yoshinori Kasahara, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 92 KB

english, 2011

35

Report on stage III Pig-a mutation assays using benzo[a]pyrene

Javed A. Bhalli, Joseph G. Shaddock, Mason G. Pearce, Vasily N. Dobrovolsky, Xuefei Cao, Robert H. Heflich, Hans-Werner Vohr

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 434 KB

english, 2011

36

Monitoring humans for somatic mutation in the endogenous pig-a gene using red blood cells

Vasily N. Dobrovolsky, Rosalie K. Elespuru, C. Anita H. Bigger, Timothy W. Robison, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2011

37

Further development of the rat Pig-a mutation assay: Measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes

Takafumi Kimoto, Satsuki Chikura, Kumiko Suzuki, Xiao mei Kobayashi, Yasuhiro Itano, Katsuyoshi Horibata, Masamitsu Honma, Vasily N. Dobrovolsky, Robert H. Heflich, Daishiro Miura, Yoshinori Kasahara

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 834 KB

english, 2011

38

Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea

Javed A. Bhalli, Mason G. Pearce, Vasily N. Dobrovolsky, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

2011

Langue:

english

Fichier:

PDF, 696 KB

english, 2011

39

Metabolism of 2-acetylaminofluorene in the chinese hamster ovary cell mutation assay

Dr. Robert H. Heflich, Daniel A. Casciano, Dr. Zhou Zhuo, Dr. Zora Djurić, Nancy F. Fullerton, Frederick A. Beland

Journal:

Environmental and Molecular Mutagenesis

Année:

1988

Langue:

english

Fichier:

PDF, 948 KB

english, 1988

40

Role of nitroreduction in the synergistic mutational response induced by mixtures of 1- and 3- nitrobenzo[a]pyrene in Salmonella typhimurium

Janice R. Thornton-Manning, Warren L. Campbell, Bruce S. Hass, James J. Chen, Peter P. Fu, Carl E. Cerniglia, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1989

Langue:

english

Fichier:

PDF, 686 KB

english, 1989

41

Induction of 6-thioguanine-resistant lymphocytes in fischer 344 rats following in vivo exposure to n-ethyl-n-nitrosourea and cyclophosphamide

Anane Aidoo, Lascelles E. Lyn-Cook, Roberta A. Mittelstaedt, Robert H. Heflich, Daniel A. Casciano, J. Cole

Journal:

Environmental and Molecular Mutagenesis

Année:

1991

Langue:

english

Fichier:

PDF, 1.76 MB

english, 1991

42

Nitro group orientation, reduction potential, and direct-acting mutagenicity of nitro-polycyclic aromatic hydrocarbons

Hyewook Jung, Robert H. Heflich, Peter P. Fu, Ali U. Shaikh, P. E. Hartman

Journal:

Environmental and Molecular Mutagenesis

Année:

1991

Langue:

english

Fichier:

PDF, 1013 KB

english, 1991

43

Analysis of solvent control and 1-Nitrosopyrene-induced chinese hamster ovary cell mutants by southern and northern blots and the polymerase chain reaction

Ronald K. Newton, Roberta A. Mittelstaedt, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1992

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1992

44

Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of chinese hamster ovary cells

Carrie R. Valentine, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1995

Langue:

english

Fichier:

PDF, 1023 KB

english, 1995

45

Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes

Roberta A. Mittelstaedt, Beverly A. Smith, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Année:

1995

Langue:

english

Fichier:

PDF, 819 KB

english, 1995

46

4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice

Tao Chen, Roberta A. Mittelstaedt, Frederick A. Beland, Robert H. Heflich, Martha M. Moore, Barbara L. Parsons

Journal:

International Journal of Cancer

Année:

2005

Langue:

english

Fichier:

PDF, 123 KB

english, 2005

47

DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide

Linda S. Von Tungeln, Mona I. Churchwell, Daniel R. Doerge, Joseph G. Shaddock, Lynda J. McGarrity, Robert H. Heflich, Gonçalo Gamboa da Costa, M. Matilde Marques, Frederick A. Beland

Journal:

International Journal of Cancer

Année:

2009

Langue:

english

Fichier:

PDF, 374 KB

english, 2009

48

Microbial transformation of the antihistaminic drug triprolidine hydrochloride

Eugene B. Hansen Jr., Robert H. Heflich, Walter A. Korfmacher, Dwight W. Miller, Carl E. Cerniglia

Journal:

Journal of Pharmaceutical Sciences

Année:

1988

Langue:

english

Fichier:

PDF, 604 KB

english, 1988

49

Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development

Barbara L. Parsons, Frederick A. Beland, Linda S. Von Tungeln, Robert R. Delongchamp, Peter P. Fu, Robert H. Heflich

Journal:

Molecular Carcinogenesis

Année:

2005

Langue:

english

Fichier:

PDF, 201 KB

english, 2005

50

Rapid isolation, hydrolysis and chromatography of formaldehyde-modified DNA

Frederick A. Beland, Nancy F. Fullerton, Robert H. Heflich

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1984

Langue:

english

Fichier:

PDF, 683 KB

english, 1984